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Stains
BG8
Last major update: June 2009
Revised: 27 June 2009
Authors: Kara Hamilton, M.S., Nat Pernick, M.D., PathologyOutlines.com, Inc.
Copyright: (c) 2002-2009, PathologyOutlines.com, Inc.
Mechanism
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● Detects the Lewis Y antigen, type 2 chain
Terminology
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● Also called Anti-Lewis-Y or Lewis Y antigen, BG-8
● Note: Methylobacter albus BG8 is a gram negative bacteria using methane as its carbon source
Uses
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● Distinguish adenocarcinoma (96-100% are positive) from mesothelioma (0-7%, AJSP 2003;27:1031, AJSP 1989;135:931, AJSP 2000;24:598, AJSP 1997;21:1409)
● Usually used in a panel, such as with calretinin and MOC-31 (Mod Pathol 2006;19:514, Pathology 2009;41:140)
Interpretation
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● Cytoplasmic staining, diffuse and intense
Positive stains - disease
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● Adenocarcinoma (96%), thymic carcinoma (Hum Pathol 2003;34:1155)
Negative stains
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● Mesothelioma (sometimes focal or weak staining in epithelium)
Micro images
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Membranous, uniform pattern in adenocarcinoma
Site unknown
Additional references
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Sources for BG8 (advertisements): Covance
End of Stains > BG8
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