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Soft Tissue Tumors Part 3
Muscle, Vascular, Nerve, Other
Epithelioid leiomyoma
Author: Nat Pernick, M.D, PathologyOutlines.com, Inc.
Revised: 13 July 2010, last major update - August 2009
Copyright: (c) 2002-2009, PathologyOutlines.com, Inc.
Leiomyoma: classic, bizarre, cutaneous, epithelioid, genital
See also: leiomyoma of deep soft tissue
Terminology
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● Called leiomyoblastoma in stomach
Case reports
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● Myxoid epithelioid leiomyoma of vulva (Gynecol Oncol 2006;103:342)
● Laryngeal tumor (Histopathology 1994;24:155)
● 42 year old woman with breast tumor with granular cell change (Hum Path 1993;24:1260),
● 48 year old man with urethral tumor (Arch Pathol Lab Med 2000;124:302)
● 50 year old woman with tumor of buccal mucosa (Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1996;82:670)
Micro description
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● Round or polygonal cells, distinct cell borders, eosinophilic cytoplasm
● May have areas of classic leiomyoma, so take more sections
● May have perinuclear halo
● May have vacuolated cytoplasm (artifact of fixation)
Micro images
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Urethral tumor: H&E,
smooth muscle actin, desmin
Positive stains
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● Desmin, smooth muscle actin
Differential diagnosis
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● PEComa - clear cells, often atypia and necrosis, HMB45+
End of Soft Tissue Tumors Part 3 - Muscle, Vascular, Nerve, Other > Epithelioid leiomyoma
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