Home Chapter Home Jobs Conferences Fellowships Books
Soft Tissue Tumors Part 3
Muscle, Vascular, Nerve, Other
Bizarre leiomyoma
Author: Nat Pernick, M.D, PathologyOutlines.com, Inc.
Revised: 13 July 2010, last major update - August 2009
Copyright: (c) 2002-2010, PathologyOutlines.com, Inc.
Leiomyoma: classic, bizarre, cutaneous, epithelioid, genital
See also: leiomyoma of deep soft tissue
Terminology
=========================================================================
● Also called symplastic, atypical and apoplectic leiomyoma
Epidemiology
=========================================================================
● Usually found in uterus; also in scrotum or skin (Am J Dermatopathol 2001;23:299)
Clinical
=========================================================================
● May recur locally after excision (Ann Diagn Pathol 2008;12:328)
Case reports
=========================================================================
● 59 year old man with scrotal mass (Cases J 2008 Dec 9;1(1):381)
● 68 year old woman with thigh nodule (Dermatology Online Journal 15(3):6)
● 69 year old man with scrotal mass (Archives 2004;128:e37)
Micro description
=========================================================================
● Large, atypical nuclei in otherwise normal appearing leiomyoma
● No/rare mitotic figures
● Suggested classification for vulvar tumors is based on number of features below (0-1 - leiomyoma, 2 - atypical leiomyoma, 3-4 - leiomyosarcoma)
(a) 5+ cm in greatest dimension
(b) infiltrative margins
(c) 5+ mitotic figures per 10 hpf
(d) moderate to severe cytologic atypia (AJSP 1996;20:779)
Micro images
=========================================================================
Smooth muscle cells with focal atypia
Positive stains
=========================================================================
● Desmin, smooth muscle actin, muscle specific actin, vimentin (Mod Pathol 1998;11:282)
Negative stains
=========================================================================
● Keratin, GFAP
References
=========================================================================
● Scrotal tumors - Mod Path 1998;11:282
End of Soft Tissue Tumors Part 3 - Muscle, Vascular, Nerve, Other > Bizarre leiomyoma
This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must also be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.
All information on this website is protected by Copyright, (c) 2001-2009, PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at copyrightPathOut@gmail.com with any questions.