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CD Markers
CD48
Reviewers: Nat Pernick, M.D., PathologyOutlines.com (see Reviewers page)
Revised: 24 December 2010, last major update December 2010
Copyright: (c) 2002-2010, PathologyOutlines.com, Inc.
General
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● Activation associated cell surface glycoprotein active in lymphocytes
Terminology
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● Also called B-lymphocyte activation marker Blast-1
Physiology
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● Glycosyl phosphatidylinositol (GPI) anchored surface molecule that mediates T cell activation by binding to CD2 (J Immunol 2009;182:7672)
● Induces numerous effects in B and T lymphocytes, natural killer cells, mast cells and eosinophils, partly based on its interaction with 2B4 / CD244 (Int J Biochem Cell Biol 2011;43:25)
● Regulates NK cell effector function (Blood 2006;107:3181)
Clinical features
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● Mast cell response to M. tuberculosis is mediated by CD48 (J Immunol 2003;170:5590)
Uses for pathologists
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● No significant clinical uses for pathologists
Positive stains - normal
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● Lymphocytes, monocytes, granulocytes (weak)
Negative stains
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● Platelets, fibroblasts, epithelium, endothelium; usually dendritic cells (J Immunol 2005;175:3690)
Additional references
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End of CD Markers > CD48
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