CD Markers - CD44R

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CD Markers

CD44R

Reviewers: Nat Pernick, M.D. (see Reviewers page)
Revised: 17 January 2011, last major update January 2011
Copyright: (c) 2002-2011, PathologyOutlines.com, Inc.

General
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● Heterogeneous group of CD44 variant isoforms expressed constitutively in epithelial cells and monocyte lineage cells; upregulated in activated leukocytes
● See CD44 for more information

Terminology
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● Also called CD44v, CD44v9

Physiology
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● Transcripts for CD44 undergo complex alternative splicing, causing functionally distinct isoforms, whose nature has not yet been determined
● Cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration

Uses for pathologists
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● No significant clinical uses for pathologists

Positive stains - disease
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● Colonic adenocarcinoma (Biochem Biophys Res Commun 1994;200:1015)

End of CD Markers > CD44R

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