CD Markers - CD11

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CD Markers

CD11

Reviewers: Nat Pernick, M.D., (see Reviewers page)
Revised: 20 December 2010, last major update December 2010
Copyright: (c) 2002-2010, PathologyOutlines.com, Inc.

General
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● Alpha component of various integrins (CD11a, CD11b, CD11c, CD11d)
● Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain

Physiology
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● Adhesion molecules of the beta2 integrin family (CD11/CD18) plays an essential role in neutrophil recruitment and activation during inflammation

Clinical features
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● Deficiency of the CD18 component (leukocyte adhesion deficiency) is a rare, inherited disorder, causing recurrent severe bacterial infections early in life, possibly fatal (OMIM 116920, Hematol Oncol Clin North Am 1988;2:13)

End of CD Markers > CD11

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